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Human IL18 Protein, Recombinant


產(chǎn)品貨號(hào):PR00257HuP1
   
詢價(jià)

規(guī)格    100ug

產(chǎn)品名稱Human IL18 Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內(nèi)毒素/
 
生物活性/
 
序列起止Tyr37~Asp193
 
標(biāo)簽N-His tag
 
Uniprot鏈接Q14116
 
表達(dá)系統(tǒng)E.coli
 
種屬Human
 
預(yù)測(cè) N 端Met
 
預(yù)測(cè)分子量17.27 kDa
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運(yùn)輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲(chǔ)存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復(fù)溶Please refer to COA for detailed information
 
質(zhì)量驗(yàn)證圖:/

別稱IGIF, IL-1g, IL1F4, IL1-F4, Interferon-Gamma-Inducing Factor, Interleukin-1 Family Member 4, Iboctadekin, Interleukin-1 Gamma
 
背景信息IL-18/IL-1F4. Interleukin-18 (IL-18) is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes,  gamma δ T cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases.IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation (1-3). IL-18 binds to the widely expressedIL-18 R alpha  which recruits IL-18 R beta  to form the signaling receptor complex (4, 5). Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs (6). In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma  production and the cytolytic activity of CD8+ T cells and NK cells (7, 8). In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils (9, 10). In the presence of IL-1 beta  or IL-23, IL-18 induces the antigen-independent production of IL-17 by  gamma δ T cells and CD4+ T cells (11).IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst (12, 13). In cancer, IL-18 exhibits diverse activities including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis (14). Mature human IL-18 shares approximately 63% amino acid sequence identity with mouse and rat IL-18 (15). Alternative splicing in human ovarian cancer generates an isoform that is resistant to Caspase-1 activation (16). A cell surface form can be expressed on M-CSF induced macrophages and released in response to bacterial endotoxin (17).

全稱Interleukin-18 (IL18)

說明書待上傳