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Human TGFBR2 Protein, Recombinant

產(chǎn)品貨號(hào):PR00424HuP1
   
詢價(jià)

規(guī)格:100ug

產(chǎn)品名稱Human TGFBR2 Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內(nèi)毒素/
 
生物活性/
 
序列起止Thr23~Gln166
 
標(biāo)簽C-His tag
 
Uniprot鏈接P37173
 
表達(dá)系統(tǒng)E.coli
 
種屬Human
 
預(yù)測(cè) N 端Met
 
預(yù)測(cè)分子量15.84 kDa
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運(yùn)輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲(chǔ)存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復(fù)溶Please refer to COA for detailed information
 
別稱MFS2
 
背景信息TGF-beta RII. Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.The recombinant soluble TGF-beta  Type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta  Type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta.
 
全稱TGF-beta receptor type-2 (TGFBR2)
 
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