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Human CTSB Protein, Recombinant

產(chǎn)品貨號(hào):PR00450HuP1
   
詢價(jià)

規(guī)格:100ug

產(chǎn)品名稱Human CTSB Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內(nèi)毒素/
 
生物活性/
 
序列起止Leu80~Asp333
 
標(biāo)簽C-His tag
 
Uniprot鏈接P07858
 
表達(dá)系統(tǒng)E.coli
 
種屬Human
 
預(yù)測(cè) N 端Met
 
預(yù)測(cè)分子量27.94kDa
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運(yùn)輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲(chǔ)存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復(fù)溶Please refer to COA for detailed information
 
別稱CTS-B, APPS, CPSB, APP secretase
 
背景信息Cathepsin B. Cathepsin B is the first described member of the family of lysosomal cysteine proteases (1). Cathepsin B possesses both endopeptidase and exopeptidase activities, in the latter case acting as a peptidyl-dipeptidase. It is known to process a number of proteins, including pro and active caspases, prorenin and secretory leucoprotease inhibitor (SLPI) (2 - 4). Therefore, Cathepsin B may play a role in activation and inactivation of caspases, activation of renin and inactivation of SLPI, the key steps in apoptosis, angiotensin production, and progression of emphysema, respectively. Because of its increased levels and redistribution of the enzyme in human and animal tumors, Cathepsin B may also have role in invasion and metastasis (5).In addition to lysosome, Cathepsin B can be secreted or associated with plasma membrane, cytoplasm, and nucleus. It is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme (1).
 
全稱Cathepsin B (CTSB)
 
說(shuō)明書待上傳