Human IFNG Protein, Recombinant
產(chǎn)品貨號(hào)：PR00017HuP1
$ 詢(xún)價(jià)
規(guī)格 100ug
產(chǎn)品名稱(chēng)：Human IFNG Protein, Recombinant
純度：≥95 % as determined by SDS-PAGE
內(nèi)毒素：< 1.0 EU per μg of the protein as determined by the LAL method
生物活性：/
序列起止：Gln24~Gly161
標(biāo)簽：N-His tag
Uniprot鏈接：P01579
表達(dá)系統(tǒng)：E.coli
種屬：Human
預(yù)測(cè) N 端：Met
預(yù)測(cè)分子量：/
緩沖液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
運(yùn)輸方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
穩(wěn)定性 & 儲(chǔ)存條件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
復(fù)溶：Please refer to COA for detailed information
質(zhì)量驗(yàn)證圖：/
別稱(chēng)：IFN-G, IFG, IFI, INFr, IFN, Immune Interferon
背景信息：IFN-gamma. Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature canine IFN-gamma exists as a noncovalently linked homodimer of 20?25 kDa variably glycosylated subunits (3). It shares 79%?88% amino acid sequence identity with bovine, equine, and feline IFN-gamma, 62%?73% with human, porcine, and rhesus IFN-gamma, and 40%-47% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up?regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).
全稱(chēng)：Interferon gamma (IFNG)
說(shuō)明書(shū)：待上傳