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Human IL2 Protein, Recombinant

產品貨號:PR00020HuP1
   
詢價

規(guī)格    100ug

產品名稱Human IL2 Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內毒素/
 
生物活性/
 
序列起止Ala21~Thr153
 
標簽N-His tag
 
Uniprot鏈接P60568
 
表達系統E.coli
 
種屬Human
 
預測 N 端Met
 
預測分子量14.63 kDa
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復溶Please refer to COA for detailed information
 
質量驗證圖:/

別稱TCGF, Lymphokine, T-Cell Growth Factor, Aldesleukin
 
背景信息IL-2. Bovine Interleukin-2 (IL-2) is a 15 kDa,  alpha -helical, single chain, potentially glycosylated polypeptide that has potent stimulatory activity for antigen-activated T cells (1 - 5). The molecule is synthesized as a 155 amino acid (aa) precursor that contains a 20 aa signal peptide plus a 135 aa mature segment that is possibly O-glycosylated (4, 5). The mature region has multiple  alpha -helices and one intrachain disulfide bond. Mature bovine IL-2 is 64%, 60%, 49%, 50%, 72%, 63% and 67% to mature human, canine, mouse, rat, porcine, equine, and feline IL-2, respectively. Mammalian cells known to express IL-2 include CD4+ and CD8+ T cells, visceral smooth muscle cells, eosinophils,  gamma δ T cells, B cells and dendritic cells. The receptor for IL-2 is complex and consists of three distinct subunits in varying combinations (6, 7). Two of these are ligand-binding and are termed IL-2 R alpha  and IL-2 R beta. IL-2 R alpha  is 55 kDa and binds IL-2 with low affinity. IL-2 R beta  is 75 kDa and binds IL-2 with intermediate affinity. Signal transduction is performed by both IL-2 R beta  and a 64 kDa common gamma chain ( gamma c). This signal transducing common gamma chain does not bind IL-2, but does heterodimerize with IL-2 R beta  to form a functional IL-2 receptor. The complex heterotrimeric  alpha -beta -gamma c receptor may arise from IL-2 binding to preformed R alpha -R beta  complexes (8). Functionally, IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells into active G1, inducing IL-2 and IL-2 R alpha  synthesis and cell proliferation (7). It also promotes Fas-induced death of naïve CD4+ T cells, while having minimal effect on activated CD4+ memory lymphocytes. Finally, IL-2 seems to play a central role in the expansion and maintenance of CD4+ CD25+ regulatory T cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity (9, 10).

全稱Interleukin-2 (IL2)
 
說明書待上傳