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Human IL1B Protein, Recombinant


產(chǎn)品貨號:PR00080HuM1
   
詢價

規(guī)格    100ug

產(chǎn)品名稱Human IL1B Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內(nèi)毒素< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性/
 
序列起止Ala117~Ser269
 
標簽N-His tag
 
Uniprot鏈接P01584
 
表達系統(tǒng)293F
 
種屬Human
 
預測 N 端Met
 
預測分子量/
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復溶Please refer to COA for detailed information
 
質(zhì)量驗證圖/

別稱IL1-B, IL1-Beta, IL1F2, IL-1β, Interleukin-1 Family Member 2, Catabolin
 
背景信息IL-1 beta/IL-1F2. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha  (IL-1F1) and IL-1 beta  (IL-1F2), which are the products of distinct genes. IL-1 alpha  and IL-1 beta  are structurally related polypeptides that share approximately 27% amino acid (aa) identity in equine. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha  and IL-1 beta  are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha  or IL-1 beta  and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta  but functions as a decoy receptor and negative regulator of IL-1 beta  activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha  and IL-1 beta  from interacting with IL-1 RI (1 - 4). The equine IL-1 beta  cDNA encodes a 268 aa precursor. A 115 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5 - 7). An alternatively spliced form of equine IL-1 beta  has a deletion which encompasses the Caspase-1 cleavage site and potentially results in a membrane-associated form (8). The 17 kDa mature equine IL-1 beta  shares 65% - 75% aa sequence identity with canine, cotton rat, feline, human, mouse, porcine, rat, and rhesus IL-1 beta.

全稱Interleukin-1 beta (IL1B)
 
說明書待上傳