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Human IL6 Protein, Recombinant


產(chǎn)品貨號(hào):PR00167HuM1
   
詢(xún)價(jià)

規(guī)格    100ug

說(shuō)明書(shū)

產(chǎn)品名稱(chēng)Human IL6 Protein, Recombinant
 
純度≥95 % as determined by SDS-PAGE
 
內(nèi)毒素< 1.0 EU per μg of the protein as determined by the LAL method
 
生物活性/
 
序列起止Val30~Met  212
 
標(biāo)簽N-His tag
 
Uniprot鏈接P05231
 
表達(dá)系統(tǒng)293F
 
種屬Human
 
預(yù)測(cè) N 端Met
 
預(yù)測(cè)分子量/
 
緩沖液20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
 
運(yùn)輸方式This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
穩(wěn)定性 & 儲(chǔ)存條件Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
 
復(fù)溶Please refer to COA for detailed information
 
質(zhì)量驗(yàn)證圖/

別稱(chēng)MGI2-A, MGI2A, HGF, BSF2, HSF, IFNB2, B-Cell Stimulatory Factor-2, Hybridoma/Plasmacytoma Growth Factor, Hepatocyte Stimulating Factor, Cytotoxic T-Cell Differentiation Factor
 
背景信息IL-6. Interleukin-6 (IL-6) is a pleiotropic,  alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1-5). Mature feline IL-6 is 181 amino acids (aa) in length and shares 56%, 35%, 38%, and 76% aa sequence identity with human, mouse, rat, and canine IL-6, respectively IL-6 (6, 7). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha  association with gp130 and gp130 dimerization (8). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (9). Soluble forms of IL-6 R alpha  are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha  elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha  (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha  is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha  but not from other cytokines that use gp130 as a co-receptor (5, 10). IL-6, along with TNF-alpha  and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1-5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 11).

全稱(chēng)Interleukin-6 (IL6)