Anti-CD68 Antibody, Rabbit Polyclonal
產(chǎn)品編號(hào)：PA00065HuA10
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產(chǎn)品名稱：Anti-CD68 Antibody, Rabbit Polyclonal
經(jīng)驗(yàn)證的應(yīng)用：WB/ICC
交叉反應(yīng)：/
特異性：human CD68
免疫原：A synthetic peptide of human CD68; UniprotKB: P34810
制備方法：Produced in rabbits immunized with human CD68, and purified by antigen affinity chromatography.
來源：Polyclonal Rabbit IgG
純化：Immunogen affinity purified
緩沖液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
偶聯(lián)物：Unconjugated
狀態(tài)：Liquid
運(yùn)輸方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
儲(chǔ)存條件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
圖片：
Figure1.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lymphoma sections labelling CD68 with purified PA00065HuA10 at 10ug/ml. Heat mediated antigen retrieval was performed using EDTA buffer (pH 9.0) . Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.
別稱：CD68, GP110, Macrosialin, Macrophage Antigen CD68
背景信息：CD68/SR-D1. CD68, also called Scavenger Receptor D1(SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoproteinthat belongs to the LAMP family (1). Human CD68 contains 354 amino acids (aa), witha 21 aa signal sequence and a 298 aa extracellular domain (ECD), a 25 aatransmembrane domain, and a 10 aa cytoplasmic domain. The ECD of CD68 has 9 glycosylation sites and a mucin-like region in aa 23-140. Within the ECD, humanCD68 shares a 65% and 67% amino acid sequence identity with that of mouse andrat CD68, respectively. CD68 is expressed onmonocytes and tissue macrophages and serves as a scavenger receptor foroxidized LDL (2). In contrast to other members of the LAMP-family ofglycoproteins which are ubiquitously expressed in all cell types, CD68 appearedto have a more restricted, cell-type specific pattern of expression (3 ,4). CD68 is alsoa biomarker of rheumatoid arthritis and Hodgkin's lymphoma (5, 6). CD68influences the functions of cells through NF-kB/focal adhesion kinase pathway (7).In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 toenhance the cell immunity (8).
全稱：Macrosialin (CD68)